STUDY DATA OF KRAS- AND RAS-UNMUTATED (WILD) TYPE OF COLORECTAL CANCER

STUDY DATA OF KRAS- AND RAS-UNMUTATED (WILD) TYPE OF COLORECTAL CANCER

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Analysis of latest trials, comparing salamander chameleon treatment schemes including chemotherapy with anti-EGFR monoclonal antibodies or bevacizumab is presented in this article.The data in these trials is inconsistent, but detailed analysis of FIRE-3 trial allows to distinguish a wild-type RAS patient group that benefits most from chemotherapy with cetuximab or panitumumab as 1st line metastatic colorectal cancer treatment.A final analysis of this patient group in azalea mrs gg gerbing CALGB/SWOG 80 405 trial is pending.The RAS analysis is pivotal for choice of 1st line chemotherapy.